纳米材料，食品分析，烟草分析，生物分析，医学诊断
招收学术型及专业学位硕士研究生！学术型及专业学位博士研究生！
相关研究方向：
1.与疾病相关的生物医学检测（蛋白质、酶、DNA等多标志物联合检测）;
2.肿瘤和神经退行性疾病的诊断和治疗研究;
3.环境、食品中农药残留、重金属等有害物质的灵敏检测方法研究;
4.食品、烟草、化妆品中香精香料的检测分析
5.食品、烟草中的风味物质（咸、甜、苦、涩、酸）检测传感研究
6.新型纳米材料的合成及其在分析化学（光谱及电化学）研究中的应用。
研究项目：
1. 同时检测阿尔茨海默症关键酶活性的方法研究，22274020，国家自然科学基金面上项目，2023.1-2026.12.
2. 香气释放原位检测。2022.3-2024.12.
3. 烟碱的电化学检测。2022.3-2023.12.
4. 粮食中有机磷和氨基甲酸酯类农药残留荧光快速检测技术开发。2022.6-2023.1
5. 聚ADP核糖聚合酶的高通量检测及其生物医学应用研究, 21775019,国家自然科学基金面上项目，2018.1-2021.12.
6. 食品安全化学性污染物智能化现场快速检测技术及相关产品研发,科技部重点研发项目，2018YFC1602800，项目骨干. 2018 年07 月-2021 年12 月
7. 单胺氧化酶的检测。2021.7-2.22.7。
8. DNA功能化组装及其在肺癌检测和治疗中的应用研究，21475020, 国家自然科学基金，2015.1-2018.12
9. 基于纳米探针的DNA损伤检测新方法及其在化学品基因毒性评价中的应用, 21205014国家自然科学基金青年基金，
10. 基于DNA损伤检测的化学品基因毒性评价与筛查新方法, BK2012734,江苏省自然科学基金合同经费10万，2012.9-2014.12
11. bet体育365官网网站-南京医科大学合作项目（重点项目）：基于血清淀粉蛋白A纳米抗体的肺癌早期检测新方法研究。2018-2020 (2242018K3DN04)
12. bet体育365官网网站基础科研业务费.高水平论文
13. 南京大学生命分析化学教育部重点实验室开放课题。SKLACLS1715. 2017-2018.
近五年发表论文：
2023
1.Xiaolei Song, Qin Ding, Wei Wei,* Juan Zhang, Rongli Sun,Lihong Yin, Songqin Liu, Yuepu Pu*. Peptide-functionalized prussian bluenanomaterial for antioxidant stress and NIR photothermal therapy againstAlzheimer’s disease. Small，2023, DOI: 10.1002/smll.202206959.
2022
1. Duoduo Zhang, Wei Wei*, Yong Liu, Yuepu Pu, Songqin Liu. Dual Imaging of Poly(ADP-ribose) Polymerase-1 and Endogenous H2O2 for the Diagnosis of Cancer Cells Using Silver-Coated Gold Nanorods. Anal. Chem. 2021, 93, 48, 16248–16256.
2. Nan Jiang, Peng Li*, Shihao Sun, Wei Wei*. A ratiometric fluorescence sensor for 5-hydroxymethylfurfural detection based on strand displacement reaction. Talanta, 238 (2022) 123029-123035.
3. Mengke Liu, Peng Li*, Haitang Yang, Nan Jiang, Dingzhong Wang, Shihao Sun，Wei Wei*. Detection of 5-hydroxymethylfurfural Based on split-DNAzyme Assisted Signal Amplification via Quartz Crystal Microbalance, Sensors & Actuators: B. Chemical 352 (2022) 131031
4. Yanhua Tang, Duoduo Zhang, Ye Lu, Songqin Liu, Juan Zhang, Yuepu Pu, Wei Wei*. Fluorescence Imaging of FEN1 Activity in Living Cells Based on Controlled-Release of Fluorescence Probe from Mesoporous Silica Nanoparticles. Biosensors and Bioelectronics, 2022, 214, 114529-114536.
5. Xiaoya Wang, Xiaolei Song, Peng Li*, Shihao Sun, Jian Mao, Songqin Liu, Wei Wei,*Fluorescence method for monoamine oxidase B detection based on the cage function of glyoxal and phenethylamine on G-rich DNA. Sensors and Actuators B: Chemical, 2022, 372, 132624-132630.
6. Duoduo Zhang , Nan Jiang, Peng Li, Yusheng Zhang, Shihao Sun, Songqin Liu, Wei Wei,*Sensitive Detection of Monoamine oxidase B Based on Localized Surface Plasmon Resonance Induced by Silver Deposited Gold Nanostar. Chem. Commun. 2022,58, 12329 - 12332. DOI: 10.1039/d2cc05139g
2021
7. Duoduo Zhang, Wei Wei*, Yong Liu, Yuepu Pu, Songqin Liu. Dual Imaging of Poly(ADP-ribose) Polymerase-1 and Endogenous H2O2 for the Diagnosis of Cancer Cells Using Silver-Coated Gold Nanorods. Anal. Chem. 2021, 93, 48, 16248–16256.
8. Xiaolei Song, Qin Ding, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei*,Yuepu Pu*, and Songqin Liu. A Smart Catalyzed Hairpin Assembly-Induced DNAzyme Nanosystem for Intracellular UDG Imaging. Anal. Chem. 2021,93, 13687−13693.
9. Duoduo Zhang, Kan Wang, Wei Wei,*Yong Liu, Songqin Liu. Multifunctional Plasmonic Core-Satellites Nanoprobe for Cancer Diagnosis and Therapy Based on Cascade Reaction Induced by MicroRNA. Anal. Chem. 2021, 93, 27, 9521-9530.
10. Haitang Yang, Chenchen Wang, Ensheng Xu, Yong Liu, Wei Wei *, Songqin Liu. Dual Mode FEN1 Activity Detection Based on Nt.BstNBI Induced Tandem Signal Amplification. Anal. Chem.,2021, 93, 11, 4960–4966.
12. Xiaolei Song, Qin Ding, Yuepu Pu, Juan Zhang, Rongli Sun, Lihong Yin, Wei Wei *. Application of the Dimeric G-Quadruplex and toehold-mediated strand displacement reaction for fluorescence biosensing of ochratoxin A. Biosensors and Bioelectronics, 2021, 192, 113537.
13. Xiaoyuan Zhou, Chenchen Wang, Lina Wu*, Wei Wei, Songqin Liu. An OliGreen-responsive Fluorescence Sensor for SensitiveDetection of Organophosphorus Pesticide Based on its Specific Selectivity towards T-Hg2+-T DNA Structure. Spectro Chimic Acta, Part A: Molecular and Biomolecular Spectroscopy, 2021, 247, 119155-119160.
14. Ensheng Xu, Haitang Yang, Peng Li, Zhuang Wang, Yong Liu, Wei Wei*, Songqin Liu. Dual-mode detection of PARP-1 by fluorescence and chemiluminescence. Sensors and Actuators B: Chemical, 2021, 330,129288-129295.
15. EnshengXu, YahuiFeng, HaitangYang, LuKong, WeiWei, SongqinLiu. Ultrasensitive and specific multi-miRNA detection based on dual signal amplification. Sensors and Actuators B: Chemical. Sensors and Actuators B: Chemical,2021, 337, 129745-129751.
2020
16. Xiaoyuan Zhou1, Chenchen Wang1, Zhuang Wang, Haitang Yang,Wei Wei,*, Yong Liu*, Songqin Liu. RenewableelectrochemicalsensorforPARP-1activitydetection basedonhost-guestrecognition. Biosensor. Bioelectron., 2020, 148，111810.
17. Duoduo Zhang, Kan Wang, Wei Wei,*Songqin Liu. Single-Particle Assay of Poly(ADP-ribose) Polymerase‑1 Activity withDark-Field Optical Microscopy. ACS Sens., 2020, 5, 1198−1206.
18. Ye Lu, Min Wei, Chenchen Wang, Wei Wei*, Yong Liu*. Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and d -amino acids. Nanoscale, 2020, 12 (8), 4959-4967.
19. Jingjiao Dong, Haitang Yang, Ying Li, Anran Liu, Wei Wei*, Songqin Liu*. Fluorescence sensor for organophosphorus pesticide detection based on the alkaline phosphatase-triggered reaction.Analytica Chimica Acta, 2020, 1131, 102e108.
20. Yong Liu, Ensheng Xu, Chao Xu, Wei Wei*. Colorimetric method for PARP-1 detection based on preventing AuNRs from etching by molybdate. Sensors and Actuators B: Chemical, 2020, 325, 128806-128812.
21. Chenchen Wang, Duoduo Zhang, Yunfei Tang, Wei Wei*, Songqin Liu. Label-Free Imaging of Flap Endonuclease 1 in Living Cells by Assembling Original and Multifunctional Nanoprobe. ACS Applied Bio Materials, 2020, 3 (7), 4573-4580.
2019
1. Zhuang Wang, Ensheng Xu, Chenchen Wang, Wei Wei*, Yong Liu, Songqin Liu. High specificity and efficiency electrochemical detection of poly(ADP-ribose) polymerase-1 activity based on versatile peptide-templated coppernanoparticles and detection array. Anal. Chim. Acta, 2019,1091，95-102.
2. Tiantian Yao, Anran Liua, Yong Liub,*, Min Weic, Wei Weia,*, Songqin Liua Ratiometric Fluorescence Sensor for Organophosphorus Pesticide Detection Based on Opposite Responses of two Fluorescence Reagents to MnO2 Nanosheets. Biosensor. Bioelectron., 2019,145, 111705
3. YeLu, Yong Liu, Chenchen Wang, Shuangshuang Wu, Wei Wei*. Fluorometric enzymatic determination of D-alanine using poly[9,9-bis(6-N,N,N-trimethylammonium)-hexyl]fluorenylene phenylene and MnO2 nanosheets, Microchim Acta, 2019, 186(7), 460
4. Ensheng Xu#, Haitang Yang#, Lina Wu*, Jin Chen, Wei Wei*, Yong Liu, Songqin Liu. Label-free poly(ADP-ribose) polymerase-1 activity assay based on perpendicular orientated mesoporous silica films". Sensors & Actuators: B. Chemical, 2019,294,185-191.
5. Chao Xu, Fen Zhang, Kan Wang, Ensheng Xu, Wei Wei*, Yong Liu, Songqin Liu。 A three-dimensional DNAzyme motor for sensitive imaging of telomerase activity in living cells. Sensors Actuator B,2019, 298,126930.
6. Haitang Yang,Ying Li, Dingzhong Wang, Yong Liu, Wei Wei *, Yuanjian Zhang, Songqin Liu, Peng Li*. Quartz crystal microbalance for telomerase sensing based on gold nanoparticles induced signal amplification. Chem Commun. 2019，55, 5994-5997.
7. Haitang Yang, Peng Li, Dingzhong Wang, Yong Liu, Wei Wei*, Yuanjian Zhang, Songqin Liu. Quartz Crystal Microbalance Detection of Poly(ADP-ribose) Polymerase-1 Based on GNRs Signal Amplification. Anal. Chem., 2019, 91, 17, 11038-11044.
8. Chenchen Wang， Ying Li， Ensheng Xu, Qing Zhou, Jin Chen, Wei Wei*, Yong Liu, Songqin Liu. A Label-free PFP-based Photoelectrochemical Biosensor for Highly Sensitive Detection of PARP-1 Activity. Biosensor. Bioelectron. 2019, 138，111308-111314.
9. Haitang Yang, Fangjia Fu, WeiLi, Wei Wei*, Yuanjian Zhang, Songqin Liu*. Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single strand DNA and poly(ADP-ribose). Chemical Science, 2019, 10, 3706 – 3714.
10. Shuang Shuang Wu, MinWei*, WeiWei*, YongLiu, SongqinLiu. Electrochemical aptasensor for aflatoxin B1 based on smart host-guest recognition of β-cyclodextrin polymer. Biosensor. Bioelectron．2019, 129, 58-63.
11. Min Wei,Chunlei Wang, Ensheng Xu, Jin Chen*, Xiaolin Xu, Wei Wei*, Songqin Liu. A simple and sensitive electrochemiluminescence aptasensor for determination of ochratoxin A based on a nicking endonuclease-powered DNA walking machine. Food Chemistry. 2019,282, 141-146.
2018
1. Peixin Li, Min Wei, Fen Zhang, juan Su, Wei Wei*, Yuanjian Zhang, Songqin Liu. A Novel Fluorescence Switch for MicroRNA Imaging in Living Cells based on DNAzyme Amplification Strategy. Acs Appl. Mater. Inter., 2018, 10 (50), pp 43405–43410。
2. Wei Wei*, Min Wei, Lihong Yin, Yuepu Pu, Songqin Liu. Improving the Fluorometric Determination of the Cancer Biomarker 8-hydroxy-2'-deoxyguanosine by using a 3D DNA Nanomachine. Microchim Acta (2018) 185: 494.
3. Shuangshuang Wu, Min Wei, Haitang Yang, Jiahui Fan, Wei Wei*, Yuanjian Zhang, Songqin Liu. Counterions-mediated gold nanorods-based sensor for label-free detection of poly(ADP-ribose) polymerase-1 activity and its inhibitor. Sensors Actuator B, 2018, 259, 565-572.
4. Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei*, Min Wei* Yuanjian Zhang, Songqin Liu. A sensitive fluorescence "turn-off-on" biosensor for poly(ADP-ribose) polymerase-1 detection based on cationic conjugated polymer-MnO2 nanosheets.Sensors Actuator B, 2018, 273, 1047-1053.
5. Chunlei Wang, Haitang Yang, Shuangshuang Wu, Yuanjian Liu, Wei Wei*, Yuanjian Zhang, Min Wei*, Songqin Liu. Manifold methods for telomerase activity detection based on various unique probes. Trends in Analytical Chemistry, 2018, 105, 404- 412.
6. Yong Liu, Bingjing Lv, Anran Liu, Geyu Liang, Lihong Yin, Yuepu Pu, Wei Wei* Songqin Liu. Multicolor sensor for organophosphorus pesticides determination based on the bi-enzyme catalytic etching of gold nanorods. Sensors Actuator B, 2018, 265, 675-681.
7. Yong Liu, Jiahui Fan, Haitang Yang, Enshen Xu, Wei Wei*, Yuanjian Zhang, Songqin Liu. Detection of PARP-1 activity based on hyperbranched-poly (ADP-ribose) polymers responsive current in artificial nanochannels. 2018, Biosensors and Bioelectronics 2018, 113, 136–141.
8. Yong Liu, Jiahui Fan, Li Shangguan, Yuanjian Liu, Yuanqing Wei, Wei Wei*, Songqin Liu. Ultrasensitive electrochemical detection of poly (ADP-ribose) polymerase-1 via polyaniline deposition. Talanta, 2018 , 180, 127-132.
9. Yong Liu, Xiaolin Xu, Haitang Yang, Ensheng Xu, Shuangshuang Wu, Wei Wei*, Jin Chen*. Analysis of poly(ADP-ribose) polymerase-1 by enzyme-initiated auto-PARylation controlled aggregation of hemin-graphene nanocomposites. Analyst, 2018, 143, 2501 - 2507.
2017
1. Xu Liu, Min Wei,Ensheng Xu,Haitang Yang,Wei Wei,* Yuanjian Zhang,Songqin Liu. A Sensitive, Label-free Electrochemical Detection of Telomerase Activity without Modification or Immobilization. Biosensors and Bioelectronics，2017, 91，347-353。
2. Xiaolin Xu, Yuanjian Liu, Xu Liu, Wei Wei,*Yuanjian Zhang, Songqin Liu. A simple, fast, label-free colorimetric method for detection of telomerase activity in urine by using hemin-graphene conjugates. Biosensors and Bioelectronics，2017, 87, 600-606. 10.1016/j.bios.2016.09.005
3. Yuanjian Liu, Min Wei, Ying Li, Anran Liu, Wei Wei, * Yuanjian Zhang, Songqin Liu. Application of spectral crosstalk correction for improving multiplexed microRNA detection using a single excitation wavelength. Anal. Chem., 2017, 89, 3430-3436。
4. Changhui Chen，Min Wei，Yuanjian Liu，Ensheng Xu，Wei Wei*，Yuanjian Zhang，Songqin Liu. Visual and fluorometric determination of telomerase activity by using a cationic conjugated polymer and fluorescence resonance energy transfer. Microchimica Acta, 2017, 184, 3453-3460.
5. Haitang Yang,# Anran Liu,# Min Wei, Yuanjian Liu, Bingjing Lv, Wei Wei,* Yuanjian Zhang, Songqin Liu*. A visual, label-free telomerase activity monitor via enzymatic etching of gold nanorods. Anal. Chem. 2017, 89, 12094-12100.
